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Body · 11 episodes

Breathwork for entrepreneurs

Breathwork shows up on this show not as relaxation for its own sake, but as a lever entrepreneurs pull to manage stress, sharpen decisions, and recover faster than their competitors. The mechanism is consistent across guests: breath is one of the only ways to consciously reach into an otherwise automatic nervous system and change its state in real time. Whether it's a founder before a pitch, a clinician calming a panicked patient, or a biohacker chasing altered states, the tool is the same.

Where guests differ is intensity and intent. Niraj Naik and John Mangogna push toward hormetic stress — long breath holds, intermittent hypoxia, deliberately uncomfortable states that force adaptation, echoing what Eric D'Agati says about physical training generally: growth comes from the response to challenge, not the challenge itself. Amy Vujadinovic and Dr. Mao Shing Ni go the opposite direction, using short, structured patterns like 5-5-7 breathing purely to downshift an overactive fight-or-flight response that was never meant to run all day. Both camps agree on the underlying physiology: breath is the fastest, cheapest input you have to your nervous system, and it works within minutes, not weeks.

The recurring warning is that most entrepreneurs are living in what D'Agati calls a 'simmering 7 or 8' — never fully activated, never fully at rest — and breathwork is one of the few tools that can reliably move you off that plateau in either direction, toward calm or toward performance, on demand.

What holds across every conversation

  • Try 5-5-7 breathing (inhale 5, hold 5, exhale 7) three times, three times a day, as a low-barrier starting protocol for calming an overactive stress response.
  • Three minutes of strong, focused deep breathing followed by a maximal breath hold has been shown to spike circulating growth hormone by up to 550% — a specific pre-performance or recovery protocol, not just a relaxation exercise.
  • Long breath holds (60–90 seconds) create intermittent hypoxia, a controlled stressor that can prompt mitochondrial renewal — treat it like interval training for your cells, not a meditation technique.
  • Use breath as a targeted tool, not a generic one: different patterns produce different outputs, so match the technique to whether you need to calm down before a hard conversation or activate before a demanding task.
  • Check your resting heart rate before and after 2-3 minutes of paced breathing — a measurable ~10 point drop is a concrete way to confirm the practice is actually shifting you into parasympathetic mode.
  • Don't wait for a dedicated retreat or program: breathwork is one of the few nervous-system interventions with meaningful effects inside a single sitting, which makes it usable between meetings, not just as a morning ritual.

Breath as a nervous system steering wheel

The most repeated idea across episodes: breath is a direct, conscious input into an otherwise automatic system, and different patterns produce different, predictable outputs.

The breath is the steering wheel of the nervous system... it literally is grabbing your nervous system by the steering wheel and guiding it in the direction you want it to go in. So if I need more focus, there's a breath for that. If I need more strength, there's a breath for that.

The Doctor of the Future Is You with Sachin Patel · 37:26· listen →

You'll notice that your resting heart rate— it's measurable— your resting heart rate will drop by about 10 points after doing 2, 3 minutes of this breathing, which is like amazing if you think about it. It's faster than taking a Xanax.

Dr. Mao Shing Ni on Energy, Qi, and Longevity Secrets · 33:53· listen →

The reason we don't take breathwork seriously is because we call it breathwork when in fact it's respiratory physiology. And if we could just understand that it's respiratory physiology and this is real and not woo, people would get more out of it perhaps.

Reset Your Nervous System for Peak Performance · 45:27· listen →

My favorite regimen because it's very easy and simple, I have 2 of them that I use in my practice, is the 5-5-7 breathing. And, that's in for 5, hold for 5, out for 7, 3 times, 3 times a day is how I usually start people.

From Survival to Strength: Breathwork & Resilience · 24:30· listen →

Hormetic stress and intentional breath holds

A harder-edged approach: deliberately holding the breath to create intermittent hypoxia, a controlled stressor that forces cellular and psychological adaptation.

So intermittent hypoxia is the magic of breathwork. When you hold your breath for 60 to 90 seconds, you invoke a positive state, a positive stress on the body, and it creates an adaptive change to having less oxygen in the body.

Niraj Naik on Breathwork, Hypoxia & Natural Highs · 9:45· listen →

When you hold your breath, right, for a long enough time, we create intermittent hypoxia and you reduce the oxygen supply to that mitochondria. You will make that mitochondria wake up and go, oh my God, I'm running out of oxygen. I need to do a spring clean.

Niraj Naik on Breathwork, Hypoxia & Natural Highs · 13:00· listen →

The idea of hormetic stress is consciously and intentionally inducing stressors in order to make adaptations. If you think about it in simple terms, it's what happens when you really strength train. When you lift weights, you're inducing a stressor to the muscles and to the fascia. There's a bit of inflammation because of that, and then you get stronger.

Reset Your Nervous System for Peak Performance · 23:27· listen →

3 minutes of deep breathing, strong, and you have to focus on it a bit, it can't be very passive, followed by a maximal voluntary breath hold increased circulating human growth hormone in the blood by up to 550% a half hour after that was done.

Reset Your Nervous System for Peak Performance · 37:45· listen →

Why fight-or-flight misfires daily

A physiological reset button is only useful because the threat response fires constantly on false alarms — traffic, email, conflict — not just genuine danger.

Fight or flight is for we're in danger. Like, fight or flight is tiger chasing me and I'm gonna die. Like, that's what fight or flight is for. Fight or flight is not for everyday living. And that's why we're seeing the high amounts of anxiety.

From Survival to Strength: Breathwork & Resilience · 16:46· listen →

So somebody honks their horn at you in traffic, you have a test at school that you're stressing out about, you're fighting with your spouse, right? It takes nothing to make that fight-or-flight response go.

From Survival to Strength: Breathwork & Resilience · 18:26· listen →

We have nociceptors that are threat receptors. Touch a hot pan, threat receptors take the information, the threatening heat, danger. That sends the signal afferently to the brain, and really through the spinal cord and the brainstem. The brain then makes processes and makes a decision on the pain perception to come back out.

Reset Your Nervous System for Peak Performance · 8:44· listen →

Breathwork's altered states and natural highs

At its most intense, rhythmic breath work produces measurable neurochemical and psychological effects that guests compare directly to psychedelic experiences.

The responses were as profound or more profound than the kind of psychedelic insights you get, um, like oneness, connection, feeling like you've been channeled by God and all that stuff, as you would from a big dose of psychedelics.

Niraj Naik on Breathwork, Hypoxia & Natural Highs · 15:31· listen →

When you hold it to as long as I was saying, intermittent hypoxia, you produce ADOSE. ADOSE standing for anandamide, dopamine, oxytocin, serotonin, and endorphins. So this makes you feel naturally high.

Niraj Naik on Breathwork, Hypoxia & Natural Highs · 30:37· listen →

Breath as decision-making and leadership tool

Beyond physiology, breath and stillness practices are framed as prerequisites for conscious, non-reactive leadership decisions.

We need to be very agile how we navigate in those times. To be agile, we need to be in that growth mindset, in that abundant mindset. So the framework helping me to pause, observe, and decide, that framework, if I practice it, I enter quickly into the abundance mindset and get out of the fear of the survival mindset.

Conscious Leadership: Deciding from Presence, Not Fear · 5:46· listen →

The first practice is the morning routine. What do you do when you start the day? Okay? And if we start by starting the day, it starts with making sure that you have a moment of silence, 5 minutes of silence. You can pray, you can meditate, you can contemplate, whatever you want. But start the journey by doing something in silence.

Conscious Leadership: Deciding from Presence, Not Fear · 31:15· listen →

My recommendation for anyone that is experiencing those things is first shake out your body, like completely shake everything out. You can even go through some tapping, through some stretching, move your body, do like a little like 5-minute yoga flow.

Burnout as a Mirror: Karenna Soto on Somatic Healing · 31:15· listen →

The companion guide

Reading about breathwork is one thing. Changing it is another.

John’s companion guide turns what these conversations cover into something you can actually work through.

More moments worth hearing

Everything else these conversations turned up on this subject.

It was in 2010 I got diagnosed with an autoimmune disease called ulcerative colitis, and that's what left me housebound for almost a year, shitting blood like 40 times a day. It was hell.

Niraj Naik on Breathwork, Hypoxia & Natural Highs · 2:20

I had shown up and fixed this exact problem I was having for so long here in Central New York, but I fixed it for everybody else. And I was very much building, the founder of a startup company, and I was not prioritizing building a support system for myself and making sure that my own social-emotional needs were being met by the people around me.

Alex Canavan: Building Community Without Burnout · 5:46

The beauty of events is that if your guests didn't plan the event, they don't know what's wrong. So, if something goes wrong, just cover it up with a smile and ask for forgiveness if you have to. At that point, there's nothing you can do.

Alex Canavan: Building Community Without Burnout · 10:19

If I don't move every day in one way or another, things get bad, so I always make that a huge priority.

Alex Canavan: Building Community Without Burnout · 14:12

I eat the same thing every day. For the most part, like down to a T. And that might sound like a little much, but honestly, it's made my life significantly easier and less stressful.

Alex Canavan: Building Community Without Burnout · 19:55

As a leader, as an entrepreneur, you're constantly having to make quick decisions all day long. You're having to solve everyone's problems. And it's just nice to have one less problem to solve.

Alex Canavan: Building Community Without Burnout · 23:28

There's just something so therapeutic about getting your thoughts out on paper and just leaving them there, you know, and not letting yourself ruminate on anything. It's been huge for me.

Alex Canavan: Building Community Without Burnout · 30:07

None of it matters if the relationships in our lives don't feel good. So that's something that I'm very proud of, that I can say that I've made that a priority.

Alex Canavan: Building Community Without Burnout · 35:19

It really is simply an invitation for us to see within ourselves where we're not honoring our unique capacity or where we have the opportunity to mature.

Burnout as a Mirror: Karenna Soto on Somatic Healing · 1:34

We are the life source of our business, right? We are the thing that gives it pulse. And if we're not taking care of ourselves, then that's, then what's the point, right? That this thing that we're creating, we won't be able to sustain it.

Burnout as a Mirror: Karenna Soto on Somatic Healing · 5:30

The lion chases the giraffe and the giraffe is running away and gets away. They immediately do this huge body shake and then they go back into rest and digest.

Burnout as a Mirror: Karenna Soto on Somatic Healing · 25:16

The challenging question that I ask a lot of entrepreneurs or people that are dabbling in their habits, I'm like, do you wanna waste 2, 3, 4 years down the line? I'm like, time is everything.

Burnout as a Mirror: Karenna Soto on Somatic Healing · 29:34

I was driving to work a couple of days ago and I saw a bald eagle and it was sitting at the very top of this very tall tree. And the wind was howling that day. It was just blowing and the snow was blowing and it was just this storm. And this eagle had its face up facing the wind on this, and it was just sitting there letting the storm beat it to death, just perfectly content.

From Survival to Strength: Breathwork & Resilience · 13:09

But I thought about that as these women were answering it. And I was like, you know, I am where I am right now. Like, I can't change it. Like, I can't change it. And so I'll say, no, I can't change it. I wouldn't change it.

From Survival to Strength: Breathwork & Resilience · 39:57

It said grief is like glitter. And if anybody's had kids or had glitter around, you know what it is, but it's like having glitter all over you and like you clean it up, but it's still in your hair and on your ears and on your skin.

From Survival to Strength: Breathwork & Resilience · 41:15

It's the same thing. You're already signaling to your brain in a very hardline way how you want to go forward as you get up.

Reset Your Nervous System for Peak Performance · 43:04

Okay, we want to achieve something, but who says we will achieve it? We decided. Okay, it's a game. So the moment I understand and come a little bit more relaxed about that, it's a game. So let's play the game the best we can. Then I become agile, then I see the waves, and then I can adjust whatever needs to be adjusted in the moment.

Conscious Leadership: Deciding from Presence, Not Fear · 20:26

In the evening, in the evening is journal. Journal things that were what you did well, and especially express gratitude towards yourself and towards the people that you had that show you did something or you received something. And by doing this act of gratitude, it increases our sense of self-worth, it increases our happiness.

Conscious Leadership: Deciding from Presence, Not Fear · 35:30

Big Joy is all about realizing that we're born for joy and not for deficits. Most of the leaders, most of the souls, most of the amazing people we work with have been taught somewhere in their journey that they're going to have to perform some version of perfection that I never figured out.

Dr. Jax Black: Redefining Success Through Joy · 4:07

There's no cliff in your soul. There's no high-performing athlete, right? If that's the example a lot of people understand as an athlete, there's no high-performing athlete who's running their fastest, jumping their highest, throwing their best right off of a cliff in their soul. No, no, no. There's no cliff. They have actually hit a zone of joy where they have whole body alignment.

Dr. Jax Black: Redefining Success Through Joy · 18:58

Every episode on breathwork

11 conversations, oldest to newest.

Niraj Naik on Breathwork, Hypoxia & Natural Highs

Intermittent hypoxia from breath holds triggers mitochondrial renewal and stem cell release, improving cellular energy and healing.

Alex Canavan: Building Community Without Burnout

A dance background instilled discipline, self-accountability, and the ability to perform even when things go wrong, which translates directly into entrepreneurship.

Burnout as a Mirror: Karenna Soto on Somatic Healing

Burnout is not just physical exhaustion but a mirror showing where you're dishonoring your unique capacity or abandoning parts of yourself.

From Survival to Strength: Breathwork & Resilience

Chronic fight-or-flight activation undermines decision-making, creativity, and healing, and simple breathing techniques can reliably interrupt it.

Reset Your Nervous System for Peak Performance

Pain is an output created by the brain's processing of threat signals, not an input from the injured body part, so changing sensory information can change pain perception.

Conscious Leadership: Deciding from Presence, Not Fear

Decisions made from fear and survival mindset produce competition and destruction, while decisions made from presence and abundance mindset align with purpose and values.

Dr. Jax Black: Redefining Success Through Joy

Joy, not deficits or trauma, is our natural born state, and fear of judgment or failure is taught by others rather than innate.

Dr. Mao Shing Ni on Energy, Qi, and Longevity Secrets

Energy, not time or intelligence, is the entrepreneur's true currency, produced through mitochondrial ATP, regulated by the nervous system, and channeled as qi in Chinese medicine.

Fitness for Busy Entrepreneurs with Eric D'Agati

Physical health works cumulatively like compound interest, not through occasional intense bursts, so consistency beats intensity.

The Doctor of the Future Is You with Sachin Patel

The healthcare system only measures disease markers, not the circadian rhythm, nervous system state, and rest/recovery patterns that actually determine health.

Bart Foster: Business Outside and the Power of Nature

Conducting business outdoors and walking shoulder-to-shoulder makes people calmer, more authentic, and more vulnerable, leading to deeper connections than coffee or lunch meetings.