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Body · 12 episodes

Metabolic Health & Blood Sugar for entrepreneurs

Ask enough guests about performance and the conversation eventually lands on the same place: blood sugar. Not as a diabetes topic, but as the thing quietly running your focus, your mood, your sleep, and your decision-making all day long. The specifics vary by guest, but the pattern doesn't. Unstable glucose shows up as afternoon crashes, bad meetings, and the second glass of wine you didn't need. Stable glucose shows up as just... having a normal day.

Where the guests agree is on mechanism: protein, fiber, and quality fat at meals blunt the swings; poor sleep and chronic stress independently wreck glucose control regardless of diet; and alcohol is the one lever nearly everyone singles out as net-negative, no matter how it's dressed up. Where they diverge is on how deep to go. Some guests want you tracking fasting glucose variability and heart rate variability as daily executive biomarkers. Others think that's overkill and that the real leverage is boringly simple — eat real food, sleep on a consistent schedule, walk more. Both camps are right for different people; the disagreement is really about how much instrumentation you personally need to stay honest.

The more clinical guests push further: type 2 diabetes and metabolic dysfunction aren't sugar problems, they're cell problems, and by the time fasting glucose looks bad, the underlying insulin resistance has usually been building for years. That reframes 'metabolic health' from a diet trend into an early-warning system — the check-engine light most entrepreneurs ignore because they're still outwardly performing.

What holds across every conversation

  • Put protein, fiber, and a quality fat on the plate at every meal — this is the single most repeated tactic across guests for stabilizing blood sugar and killing afternoon crashes.
  • Track sleep latency, cortisol timing after 10am, fasting glucose variability, and heart rate variability if you want an early warning system before symptoms appear — these are described as the '4 horsemen' of executive burnout.
  • Don't treat sleep debt as something you can bank or repay; the fix is a consistent wake time, not a consistent bedtime.
  • Get baseline blood work and a DEXA scan (roughly $50–100) before investing in anything more exotic like biological-age clocks, which aren't yet clinically validated enough to act on.
  • If you drink, know that even moderate amounts (around one drink a day) are consistently flagged as worse than zero for sleep, arteries, and liver — there's no guest making the case for net benefit.
  • Treat feeling 'fine' with suspicion: several guests describe looking outwardly fit while fasting glucose, testosterone, or kidney markers were already deteriorating for months before anything showed up as a diagnosis.

The Biomarkers Worth Tracking

Which numbers actually predict burnout and metabolic decline, versus which ones are noise.

I always look for what I call the 4 Horsemen of executive burnout. So the first one is sleep latency extending beyond 25 minutes... The second one is cortisol staying elevated after 10... There's also how your fasting glucose is going to vary during the day... The last thing is your heart rate variability when you sleep.

Dr. Emilie Laplagne: Functional Medicine for Entrepreneurs · 16:23· listen →

There was a study that showed that only 12% of Americans are actually metabolically healthy on all measures.

Dr. Emilie Laplagne: Functional Medicine for Entrepreneurs · 20:22· listen →

And by the way, bad night's sleep have a lot of an effect the day after. You make a bad decision. You are more grumpy. You have a higher chance to have higher rates and high glucose and your testosterone usually is lower. And so you are also, your cortisol, your stress is higher. You are more prone to get injured.

Biomarkers, Biological Age & the Science of Healthspan · 32:58· listen →

The 2 things I think are most foundational are blood work and DEXA scan... they're not expensive, it's like $50 to $100.

Longevity As a Competitive Edge: Jesse Levey on Health Strategy · 38:55· listen →

Insulin Resistance Is a Cell Problem

The functional-medicine case that diabetes and metabolic dysfunction start at the cellular level, long before a diagnosis shows up on a chart.

Imagine you're driving down the road and your car check engine light comes on. That's an indication that something's broken, something's not right, but your car can still drive. It's still doing its job. But so your choice is take the fuse out so you don't see the check engine light anymore, or you take it to your mechanic to get evaluated. That's functional medicine. Functional medicine is looking for the check engine lights that are going on inside your body.

Reversing Type 2 Diabetes: The Functional Medicine Approach · 0:00· listen →

The problem with high amounts of insulin into the bloodstream, it's like throwing too much water on a plant. What happens to the plant? Guys, when you throw too much insulin around an insulin receptor, so does the receptor, closes up and can't have the insulin enter. So what's that called? Insulin resistance.

Reversing Type 2 Diabetes: The Functional Medicine Approach · 10:58· listen →

But the research is very clear. There's a lot of research in PubMed that you can identify reversing type 2 diabetes by doing the right steps. Because when we look at diabetes from a blood sugar perspective, yeah, you're right, you cannot reverse it. You'll rarely, if any, ever get the person off medications if you just focus on their sugars alone. But if you focus it from a cell perspective and the cell disease, now we're talking because now we're getting to the root issue that's going on.

Reversing Type 2 Diabetes: The Functional Medicine Approach · 28:27· listen →

And literally, there were 6 months prior where the tests showed no issues. 6 months later, she was in basically 12 GFR and so the kidneys were basically done. And she was then going 3 times a week for 3 hours at a time for dialysis. 8 months later, she had a stroke and she passed.

Reversing Type 2 Diabetes: The Functional Medicine Approach · 1:24· listen →

Blood Sugar and Sleep Are the Same Lever

Guests keep pointing to a two-way loop: unstable glucose wrecks sleep, and bad sleep wrecks glucose control the next day.

Blood sugar is the number one thing for quality sleep. Blood sugar balance is the number one thing that will affect quality sleep.

Gut Health, Real Food & Detox Truths for Entrepreneurs · 26:51· listen →

And by the way, bad night's sleep have a lot of an effect the day after. You make a bad decision. You are more grumpy. You have a higher chance to have higher rates and high glucose and your testosterone usually is lower. And so you are also, your cortisol, your stress is higher. You are more prone to get injured.

Biomarkers, Biological Age & the Science of Healthspan · 32:58· listen →

This idea of a sleep deficit, it's a farce. It's not how the body works. You cannot make up this sleep deficit. So it means that every single day, we want to wake up at the same time and go to bed at the same time, within reason.

Nutrition, Sleep & Pacing for Entrepreneurs | Jenn Trepeck · 28:11· listen →

It's the Sleep Foundation that has a study that says that every single night of poor sleep can reduce cognitive performance the next day by 25%. And it's the equivalent of a blood alcohol level of 0.05%.

Dr. Emilie Laplagne: Functional Medicine for Entrepreneurs · 34:38· listen →

What to Eat: Protein, Fiber, Fat — and Fewer Seed Oils

The nutritional consensus across guests, plus the debate over industrial oils and diet-culture fat phobia.

Protein and fiber at every meal makes removing fat no big deal. Protein and fiber at every meal makes removing fat no big deal. And frankly, whether removing fat is your health goal or not, it makes health no big deal.

Nutrition, Sleep & Pacing for Entrepreneurs | Jenn Trepeck · 11:38· listen →

And I'm like, oh my gosh, butter. If I had just eaten butter, my body would have been so much more nourished and my blood sugar would have been more balanced. I would have been more satisfied. I wouldn't have experienced these extreme cravings and I just wouldn't have experienced what felt like a constant battle with my body. And now that I've changed my whole mindset and my approach to eating, it is so much simpler.

Unlearning Diet Culture: Fats, Blood Sugar & Gut Health · 8:24· listen →

So our body is like a car in one sense that we've got to have the right fuel in our tank. And yet we don't come with instructions. Our car does, but we don't. We can get a new car, you can get a new engine, but we can't get a new one of these.

Why Seed Oils Are Bad & What to Eat Instead | Cherie Calbom · 6:52· listen →

Today, we have many, many, many, many options for what we eat, and perhaps 80% of our beautiful large grocery stores, that is not best fuel for any of us. So it's maybe only 20% of that big, beautiful store So what we're eating is most critical.

Gut Health, Real Food & Detox Truths for Entrepreneurs · 6:01· listen →

Alcohol: The One Thing Nobody Defends

Across otherwise different philosophies, alcohol is the single intervention guests agree is a clear net negative for metabolic health.

Alcohol is the worst... it's still a poison, you know. It's terrible for your liver. It's just a poison for your arteries as well. And more than that, you know, it also really messes up your sleep.

Dr. Emilie Laplagne: Functional Medicine for Entrepreneurs · 28:12· listen →

Say 1 drink a day, 7 drinks a week. The general consensus that I can see is that that's probably not like really bad, but it certainly is not better than zero.

Longevity As a Competitive Edge: Jesse Levey on Health Strategy · 5:05· listen →

There are ways to create that sort of social connection of feeling like you're drinking without actually ingesting much... one of my go-to drinks is bitters and soda.

Longevity As a Competitive Edge: Jesse Levey on Health Strategy · 8:19· listen →

I'm saying it's less wrong. No, I'm, for example, I'm not drinking alcohol at all. That's the intervention that I decided to do, but that's my decision. Everyone, you know, it's at the end of the day, we need to enjoy life.

Biomarkers, Biological Age & the Science of Healthspan · 30:21· listen →

Outwardly Fit, Metabolically Broken

The uncomfortable point several guests make: you can look like you're performing well and still be quietly deteriorating on every metabolic marker that matters.

I felt like I was just putting a bandaid on a cancer basically.

Dr. Emilie Laplagne: Functional Medicine for Entrepreneurs · 2:14· listen →

70% of chronic diseases are lifestyle-related and therefore preventable today.

Dr. Emilie Laplagne: Functional Medicine for Entrepreneurs · 42:50· listen →

I started investing in my health. I had a hyperbaric chamber, the sauna, the cold plunge, massage twice a week, acupuncture twice a week, stretching, got a chef in-house. I told you, I had the ability to kind of invest in my health to play longer and I did that.

From NFL to Entrepreneurship: Justin Pugh's Playbook · 42:26· listen →

It's not just what you eat, but it's what your body can do with what you eat. So you could be eating this beautiful, by-the-book, whole foods, perfect diet, but if your body can't digest the food, then you're not able to take full advantage of all those nutrients and you might not be absorbing them.

Unlearning Diet Culture: Fats, Blood Sugar & Gut Health · 0:00· listen →

The companion guide

Reading about metabolic health & blood sugar is one thing. Changing it is another.

John’s companion guide turns what these conversations cover into something you can actually work through.

More moments worth hearing

Everything else these conversations turned up on this subject.

McKinsey conducted a study with leaders and they showed that the leaders who prioritize their own wellbeing inspired 90% higher employee satisfaction and 70% lower burnout rates in their teams.

Dr. Emilie Laplagne: Functional Medicine for Entrepreneurs · 45:34

And that always stuck with me. It's like, we already did the hard part. We made it to the NFL, which no one thought we could do. You make life-changing money. Let's get really good at saving before we ever get good at investing.

From NFL to Entrepreneurship: Justin Pugh's Playbook · 8:21

How much does it cost to be Justin Pugh or whoever's listening right now? Most people at home probably can't even tell you that. The NFL player just had a bunch of money over a very short period of time. And they didn't know how much it costs to be them.

From NFL to Entrepreneurship: Justin Pugh's Playbook · 10:50

I said, hey, if you don't like this idea, just gimme a quick no. Like, I'm not, it's no skin off your back and no, like, I just, I need to know so I'm not hanging around the hoop waiting forever because it's going to slow me down.

From NFL to Entrepreneurship: Justin Pugh's Playbook · 19:54

I remember we're on a bus ride or we're on a train ride from New York to play the Washington Commanders. And he's telling me about how he lived in a car after Katrina hit when he was a little little boy.

From NFL to Entrepreneurship: Justin Pugh's Playbook · 24:06

There's a cover-your-ass culture in the NFL because if you don't have security or you haven't won recently, you're on the line. That's coaches, that's general managers. No one wants to tell the owner bad news. So it always is someone else's fault. So the spotlight's off them and on somebody else.

From NFL to Entrepreneurship: Justin Pugh's Playbook · 28:22

Yeah, I think whoever coined that phrase was just lucky enough to have something that they really liked that paid them a lot of money, right? Because you're right, the fact is, yeah, you have to pay your bills, right? So you've got to find something that's going to pay the bills.

From NFL to Entrepreneurship: Justin Pugh's Playbook · 16:36

100%. And this is one of the reasons why when someone's like, you go to these cancer treatment centers, they recommend like ketogenic diets or carnivore type diets because you're reducing that sugar, you're getting rid of sugars completely. It just feeds it because when you bring in sugar to a cancer cell, yeah, it just thrives and just grows and grows and grows and it starts proliferating to other cancer cells and you're basically just putting gasoline on a fire.

Reversing Type 2 Diabetes: The Functional Medicine Approach · 23:55

So I came back all excited and I was like, I got my good list and everything. And I go through my list and everything and he's like, this is a really good list. I'm really impressed. He's all, but just as a question, where do you fall on that list? And I wasn't even in the top 5.

Reversing Type 2 Diabetes: The Functional Medicine Approach · 45:10

Longevity, you can look at it at a lifespan, basically the length of time that you live from birth to death. And there is what we call the healthspan, how long that you live in good health. So I assume that everyone wants to live better longer.

Biomarkers, Biological Age & the Science of Healthspan · 1:16

Yeah, it's not easy, but I don't think that anything is easy and you need to take some risks. So I took a big risk that I assumed that other people won't take. So I think that that's a big difference between entrepreneur and non-entrepreneur. It's someone that takes risks and they're willing to take the consequences of that risk.

Biomarkers, Biological Age & the Science of Healthspan · 4:14

But again, if you would ask me about caloric restriction 10 years ago, I would be very bullish. Right now I'm a bit less bullish about it because I'm not sure that this is the best intervention, especially in humans.

Biomarkers, Biological Age & the Science of Healthspan · 12:03

When you get older, it's much harder to build muscle. So if you have a younger audience, go to the gym. And I see it a lot when you go to the gym, you see much less women, especially in our age, lifting weight. And it is important.

Biomarkers, Biological Age & the Science of Healthspan · 25:24

And also, it doesn't mean that if you work 15 hours every day, you are more productive. It might be that 8 hours that you are more focused is better than 15 hours that you are less focused. So, don't come say, I'm an entrepreneur, I have to work 15 hours a day. It doesn't— it's not true.

Biomarkers, Biological Age & the Science of Healthspan · 34:29

As a human, your number one job in life is to be a professional sleeper... if you can do that, then the idea is you go to bed on time and you wake up when you're done, the same way you go to work on time and you leave work when you're done.

Longevity As a Competitive Edge: Jesse Levey on Health Strategy · 13:43

You have 2 women who have 26% body fat. One might have 1 pound of visceral fat, one might have 3 pounds. They're the same weight, the same percent body fat, but the amount of visceral fat they have is dramatically different.

Longevity As a Competitive Edge: Jesse Levey on Health Strategy · 18:09

The number one thing I think that is maybe a misnomer in this space, I think personally, is that diet is 80%, 90%, the most important thing you can focus on... it's not to say diet isn't important because it is, but this sometimes becomes a limiting belief.

Longevity As a Competitive Edge: Jesse Levey on Health Strategy · 24:45

If there is a secret to longevity, it's not a secret, it's first your lifestyle. The things that have the most proof are caloric balance, exercise, sleep, aggressive screening. There's no secrets out there.

Longevity As a Competitive Edge: Jesse Levey on Health Strategy · 27:18

My fear with a biological clock is that you're doing things that may be making it look younger on the test that doesn't actually make you younger in reality.

Longevity As a Competitive Edge: Jesse Levey on Health Strategy · 33:29

Flexibility, I think, is part of the key here. As we get older, staying as flexible as we can, as loose as we can, doing the stretches, even though I don't like doing them, it just seems like a waste of time. I'd rather be evaluating a company or doing something else versus stretching, but that keeps us from getting stiff, and stiffness leads to injuries.

Dr. Mihir Patel: Muscle Strength, Longevity & Joint Health · 0:00

Every episode on metabolic health & blood sugar

12 conversations, oldest to newest.

Dr. Emilie Laplagne: Functional Medicine for Entrepreneurs

Traditional Western medicine is siloed and reactive, treating symptoms after disease develops, while functional medicine looks at the whole body and root causes.

From NFL to Entrepreneurship: Justin Pugh's Playbook

Justin Pugh built NFL Biz Week to teach players financial literacy and deal-vetting skills because most athletes retire with no plan and high bankruptcy rates.

Reversing Type 2 Diabetes: The Functional Medicine Approach

Type 2 diabetes is fundamentally a cell disease, not just a sugar disease, driven by insulin resistance and multiple underlying dysfunctions.

Biomarkers, Biological Age & the Science of Healthspan

Longevity should be measured by healthspan, the years lived in good health, not just raw lifespan.

Longevity As a Competitive Edge: Jesse Levey on Health Strategy

Most longevity advice is overly individualized or dogmatic, but reducing alcohol and optimizing sleep benefit almost everyone.

Dr. Mihir Patel: Muscle Strength, Longevity & Joint Health

Muscle strength, mobility, and flexibility are the most important factors in preventing orthopedic injuries and staying out of the OR as we age.

Sound Therapy & Cymatics for Entrepreneur Health

Cymatics is the science of making sound visible through mediums like water, sand, or powder, where pleasing sounds form organized geometric patterns and dissonant sounds create chaotic ones.

Nutrition, Sleep & Pacing for Entrepreneurs | Jenn Trepeck

The quality of food, not just calories in/calories out, determines whether the body is set up for health or disease.

Gut Health, Real Food & Detox Truths for Entrepreneurs

Gut health underlies nearly every system in the body, from brain function and mood to skin, lungs, and joints, so poor digestion can manifest as brain fog, fatigue, or anxiety.

Cymatics & Sound Healing: John Stuart Reid Explains

Sound is not actually a wave but a spherical, pulsating bubble of energy, and cymatics makes this energy visible by imprinting it onto membranes like water.

Unlearning Diet Culture: Fats, Blood Sugar & Gut Health

Health depends not just on what you eat but on whether your body can properly digest and absorb it.

Why Seed Oils Are Bad & What to Eat Instead | Cherie Calbom

Industrial seed oils are processed with extreme heat and chemicals like hexane, creating toxic byproducts that drive oxidative stress and inflammation.